Ontology highlight
ABSTRACT:
SUBMITTER: Dajani R
PROVIDER: S-EPMC3773984 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Dajani Rana R Koo Sung-Eun SE Sullivan Gareth J GJ Park In-Hyun IH
Journal of cellular biochemistry 20131101 11
Rett syndrome (RTT) is one of most prevalent female neurodevelopmental disorders. De novo mutations in X-linked MECP2 are mostly responsible for RTT. Since the identification of MeCP2 as the underlying cause of RTT, murine models have contributed to understanding the pathophysiology of RTT and function of MeCP2. Reprogramming is a procedure to produce induced pluripotent stem cells (iPSCs) by overexpression of four transcription factors. iPSCs obtain similar features as embryonic stem cells and ...[more]