Ontology highlight
ABSTRACT:
SUBMITTER: Province MA
PROVIDER: S-EPMC3773990 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20130101
Meta-analysis is becoming an increasingly popular and powerful tool to integrate findings across studies and OMIC dimensions. But there is the danger that hidden dependencies between putatively "independent" studies can cause inflation of type I error, due to reinforcement of the evidence from false-positive findings. We present here a simple method for conducting meta-analyses that automatically estimates the degree of any such non-independence between OMIC scans and corrects the inference for ...[more]