Ontology highlight
ABSTRACT:
SUBMITTER: Mavropoulos JC
PROVIDER: S-EPMC3774034 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Mavropoulos John C JC Buschemeyer W Cooper WC Tewari Alok K AK Rokhfeld Dmitriy D Pollak Michael M Zhao Yunhua Y Febbo Phillip G PG Cohen Pinchas P Hwang David D Devi Gayathri G Demark-Wahnefried Wendy W Westman Eric C EC Peterson Bercedis L BL Pizzo Salvatore V SV Freedland Stephen J SJ
Cancer prevention research (Philadelphia, Pa.) 20090526 6
<h4>Purpose</h4>Numerous dietary factors elevate serum levels of insulin and insulin-like growth factor I (IGF-I), both potent prostate cancer mitogens. We tested whether varying dietary carbohydrate and fat, without energy restriction relative to comparison diets, would slow tumor growth and reduce serum insulin, IGF-I, and other molecular mediators of prostate cancer in a xenograft model.<h4>Experimental design</h4>Individually caged male severe combined immunodeficient mice (n = 130) were ran ...[more]