Ontology highlight
ABSTRACT:
SUBMITTER: Ingles-Prieto A
PROVIDER: S-EPMC3774310 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Ingles-Prieto Alvaro A Ibarra-Molero Beatriz B Delgado-Delgado Asuncion A Perez-Jimenez Raul R Fernandez Julio M JM Gaucher Eric A EA Sanchez-Ruiz Jose M JM Gavira Jose A JA
Structure (London, England : 1993) 20130808 9
Little is known about the evolution of protein structures and the degree of protein structure conservation over planetary time scales. Here, we report the X-ray crystal structures of seven laboratory resurrections of Precambrian thioredoxins dating up to approximately four billion years ago. Despite considerable sequence differences compared with extant enzymes, the ancestral proteins display the canonical thioredoxin fold, whereas only small structural changes have occurred over four billion ye ...[more]