Ontology highlight
ABSTRACT:
SUBMITTER: Song T
PROVIDER: S-EPMC3774361 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Song Tanjing T Yang Leixiang L Kabra Neha N Chen Lihong L Koomen John J Haura Eric B EB Chen Jiandong J
The Journal of biological chemistry 20130604 29
The chromosomal region encoding the nuclear NAD(+) synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) is frequently deleted in human cancer. We describe evidence that NMNAT1 interacts with the nucleolar repressor protein nucleomethylin and is involved in regulating rRNA transcription. NMNAT1 binds to nucleomethylin and is recruited into a ternary complex containing the NAD(+)-dependent deacetylase SirT1. NMNAT1 expression stimulates the deacetylase function of SirT1. Knock ...[more]