Dataset Information

Elevated reward region responsivity predicts future substance use onset but not overweight/obesity onset.

ABSTRACT:

Background

We tested the hypotheses that adolescents who show elevated reward region responsivity are at increased risk for initial onset of overweight/obesity and substance use, which is important because there have been no such prospective tests of the reward surfeit model of these motivated behaviors.

Methods

One hundred sixty-two adolescents (mean age = 15.3±1.06 years) with healthy weights (mean body mass index = 20.8±1.90) completed functional magnetic resonance imaging paradigms that assessed neural activation in response to receipt and anticipated receipt of palatable food and monetary reward; body fat and substance use were assessed at baseline and 1-year follow-up.

Results

Elevated caudate (r = .31, p<.001) and putamen (r = .28, p<.001) response to monetary reward predicted substance use onset over 1-year follow-up, but reward circuitry responsivity did not predict future overweight/obesity onset. Adolescents who reported substance use versus abstinence at baseline also showed less caudate (r =-.31, p<.001) response to monetary reward.

Discussion

Results show that hyper-responsivity of reward circuitry increases risk for future substance use onset, providing novel support for the reward surfeit model. Results also imply that even a limited substance use history was associated with reduced reward region responsivity, extending results from studies that compared substance-dependent individuals with healthy control subjects and suggesting that substance use downregulates reward circuitry. However, aberrant reward region responsivity did not predict initial unhealthy weight gain.

SUBMITTER: Stice E

PROVIDER: S-EPMC3774523 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Publications

Elevated reward region responsivity predicts future substance use onset but not overweight/obesity onset.

Stice Eric E Stice Eric E Yokum Sonja S Burger Kyle S KS

Biological psychiatry 20130108 9

<h4>Background</h4>We tested the hypotheses that adolescents who show elevated reward region responsivity are at increased risk for initial onset of overweight/obesity and substance use, which is important because there have been no such prospective tests of the reward surfeit model of these motivated behaviors.<h4>Methods</h4>One hundred sixty-two adolescents (mean age = 15.3±1.06 years) with healthy weights (mean body mass index = 20.8±1.90) completed functional magnetic resonance imaging para ...[more]

PMID: 23312561

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Dataset Information

Elevated reward region responsivity predicts future substance use onset but not overweight/obesity onset.

Background

Methods

Results

Discussion

Publications

Elevated reward region responsivity predicts future substance use onset but not overweight/obesity onset.

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