Dataset Information

The association of diabetes mellitus with clinical outcomes after coronary stenting: a meta-analysis.

ABSTRACT:

Background

Previous studies have shown inconsistent results on the association between diabetes mellitus (DM) and some clinical outcomes. We conducted a meta-analysis of observational studies to assess effect of DM on clinical outcomes after coronary stenting.

Methods

We searched for studies without language restriction in PubMed, Embase and Cochrane library prior to 2012. The clinical outcomes including in-stent restenosis (ISR), major adverse cardiac events (MACE), stent thrombosis (ST), target lesion revascularization (TLR) and target vessel revascularization (TVR). Adjusted odds ratio (OR), and the corresponding 95% confidence interval (95% CI) was summarized.

Results

55 studies involving 128,084 total patients (38,416 DM patients and 89,668 controls) were eligible for our analysis. Overall, there were significant associations between DM and ISR (OR = 1.70, 95% CI: 1.53-1.89, I(2) = 0.0%), MACE (OR = 1.54, 95% CI: 1.36-1.73, I(2) = 29.0%), ST (OR = 2.01, 95% CI: 1.36-2.97, I(2) = 47.7%), TLR (OR = 1.46, 95% CI: 1.26-1.68, I(2) = 43.3%) as well as TVR (OR = 1.33, 95% CI: 1.17-1.51, I(2) = 48.3). Subgroup analysis showed that the associations were similar between BMS and DES implantation. Moreover, there was no significant association in the ST subgroup after 1-3 years follow-up.

Conclusions

Our meta-analysis suggests that after coronary stent implantation, DM is associated with ISR, MACE, ST, TLR and TVR. DM appears to be a vital risk factor of these clinical outcomes.

SUBMITTER: Qin SY

PROVIDER: S-EPMC3774683 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

The association of diabetes mellitus with clinical outcomes after coronary stenting: a meta-analysis.

Qin Shan-Yu SY Zhou You Y Jiang Hai-Xing HX Hu Bang-Li BL Tao Lin L Xie Min-zhi MZ

PloS one 20130916 9

<h4>Background</h4>Previous studies have shown inconsistent results on the association between diabetes mellitus (DM) and some clinical outcomes. We conducted a meta-analysis of observational studies to assess effect of DM on clinical outcomes after coronary stenting.<h4>Methods</h4>We searched for studies without language restriction in PubMed, Embase and Cochrane library prior to 2012. The clinical outcomes including in-stent restenosis (ISR), major adverse cardiac events (MACE), stent thrombo ...[more]

PMID: 24066025

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Dataset Information

The association of diabetes mellitus with clinical outcomes after coronary stenting: a meta-analysis.

Background

Methods

Results

Conclusions

Publications

The association of diabetes mellitus with clinical outcomes after coronary stenting: a meta-analysis.

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