Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma.

ABSTRACT:

Objective

To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC.

Patients and methods

Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous (n = 20) and ESCC (n = 64).

Results

Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC (P = 0.001). The expression of FXYD-3 was correlated with TNM stages and depth of tumor invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis (P = 0.086), and FXYD-3 expression tended to be positively related to the expression of PINCH (P = 0.063). Moreover, the cases positive for both protei

SUBMITTER: Zhu ZL 

PROVIDER: S-EPMC3774971 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature