The measles virus phosphoprotein interacts with the linker domain of STAT1.
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ABSTRACT:
SUBMITTER: Devaux P
PROVIDER: S-EPMC3775481 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
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The measles virus phosphoprotein interacts with the linker domain of STAT1.
Devaux Patricia P Priniski Lauren L Cattaneo Roberto R
Virology 20130713 1-2
The measles virus (MV) phosphoprotein (P) and V proteins block the interferon (IFN) response by impeding phosphorylation of the signal transducer and activator of transcription 1 (STAT1) by the Janus kinase 1 (JAK1). We characterized how STAT1 mutants interact with P and JAK1 phosphorylation. Certain mutants of the linker, the Src-homology 2 domain (SH2), or the transactivation domain had reduced or abolished phosphorylation through JAK1 after IFN treatment. Other mutants, mainly localized in th ...[more]
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