Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura J
PROVIDER: S-EPMC3775512 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Bioscience reports 20130917 5
IF1 is an endogenous inhibitor protein of mitochondrial ATP synthase. It is evolutionarily conserved throughout all eukaryotes and it has been proposed to play crucial roles in prevention of the wasteful reverse reaction of ATP synthase, in the metabolic shift from oxidative phosphorylation to glycolysis, in the suppression of ROS (reactive oxygen species) generation, in mitochondria morphology and in haem biosynthesis in mitochondria, which leads to anaemia. Here, we report the phenotype of a m ...[more]