Dataset Information

Thigh circumference and diabetes: obesity as a potential effect modifier.

ABSTRACT:

Background

Thigh circumference is associated with diabetes risk; however, the role of obesity as a potential effect modifier has not been well studied.

Methods

We examined the association between thigh circumference and diabetes in a cross-sectional study of 384 612 Koreans aged 30 to 79 years. The association between diabetes and thigh circumference in relation to body mass index (BMI) was analyzed among 315 628 participants, using multivariate logistic regression. Thigh circumference was categorized into 9 percentile categories-namely, the 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, and 97.5th percentiles-and the 50th percentile was used as the reference value for thigh circumference. Separate analyses were performed for men and women.

Results

The association of thigh circumference with diabetes showed contradictory patterns before and after adjustment for BMI and waist circumference. Small thigh circumference was associated with greater risk of diabetes among men and women. This relationship was stronger among participants younger than 50 years, although age was not a significant effect modifier. BMI was a significant effect modifier among men with a BMI of less than 25 kg/m(2). Among women, diabetes risk increased with smaller thigh circumference.

Conclusions

Small thigh circumference was associated with diabetes, and this association was stronger among participants with a BMI of less than 25 kg/m(2). Thigh circumference might be a useful diabetes marker in lean populations.

SUBMITTER: Jung KJ

PROVIDER: S-EPMC3775526 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Publications

Thigh circumference and diabetes: obesity as a potential effect modifier.

Jung Keum Ji KJ Kimm Heejin H Yun Ji Eun JE Jee Sun Ha SH

Journal of epidemiology 20130727 5

<h4>Background</h4>Thigh circumference is associated with diabetes risk; however, the role of obesity as a potential effect modifier has not been well studied.<h4>Methods</h4>We examined the association between thigh circumference and diabetes in a cross-sectional study of 384 612 Koreans aged 30 to 79 years. The association between diabetes and thigh circumference in relation to body mass index (BMI) was analyzed among 315 628 participants, using multivariate logistic regression. Thigh circumfe ...[more]

PMID: 23892710

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Project description:IntroductionType 2 diabetes patients have abdominal obesity and low thigh circumference. Previous studies have mainly focused on the role of exercise in reducing body weight and fat mass, improving glucose and lipid metabolism, with a lack of evaluation on the loss of muscle mass, diabetes complications, energy metabolism, and brain health. Moreover, whether the potential physiological benefit of exercise for diabetes mellitus is related to the modulation of the microbiota-gut-brain axis remains unclear. Multi-omics approaches and multidimensional evaluations may help systematically and comprehensively correlate physical exercise and the metabolic benefits.Methods and analysisThis study is a randomized controlled clinical trial. A total of 100 sedentary patients with type 2 diabetes will be allocated to either an exercise or a control group in a 1:1 ratio. Participants in the exercise group will receive a 16-week combined aerobic and resistance exercise training, while those in the control group will maintain their sedentary lifestyle unchanged. Additionally, all participants will receive a diet administration to control the confounding effects of diet. The primary outcome will be the change in body fat mass measured using bioelectrical impedance analysis. The secondary outcomes will include body fat mass change rate (%), and changes in anthropometric indicators (body weight, waist, hip, and thigh circumference), clinical biochemical indicators (glycated hemoglobin, blood glucose, insulin sensitivity, blood lipid, liver enzyme, and renal function), brain health (appetite, mood, and cognitive function), immunologic function, metagenomics, metabolomics, energy expenditure, cardiopulmonary fitness, exercise-related indicators, fatty liver, cytokines (fibroblast growth factor 21, fibroblast growth factor 19, adiponectin, fatty acid-binding protein 4, and lipocalin 2), vascular endothelial function, autonomic nervous function, and glucose fluctuation.DiscussionThis study will evaluate the effect of a 16-week combined aerobic and resistance exercise regimen on patients with diabetes. The results will provide a comprehensive evaluation of the physiological effects of exercise, and reveal the role of the microbiota-gut-brain axis in exercise-induced metabolic benefits to diabetes.Clinical trial registrationhttp://www.chictr.org.cn/searchproj.aspx, identifier ChiCTR2100046148.

Dataset Information

Thigh circumference and diabetes: obesity as a potential effect modifier.

Background

Methods

Results

Conclusions

Publications

Thigh circumference and diabetes: obesity as a potential effect modifier.

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