A fluorescence-based assay for p38? recruitment site binders: identification of rooperol as a novel p38? kinase inhibitor.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3775607 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
A fluorescence-based assay for p38α recruitment site binders: identification of rooperol as a novel p38α kinase inhibitor.
Li Jing J Kaoud Tamer S TS LeVieux Jake J Gilbreath Brad B Moharana Swapna S Dalby Kevin N KN Kerwin Sean M SM
Chembiochem : a European journal of chemical biology 20121206 1
A new p38α inhibitor: Using a D-recruitment site (DRS) probe for p38α which exploits covalent interaction with Cys119 and alkyne-azide "click" chemistry to identify small molecules that recognize the p38α DRS, the anti-inflammatory natural product rooperol was identified as a novel p38α inhibitor. ...[more]
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