Dataset Information

Estimation of CT-derived abdominal visceral and subcutaneous adipose tissue depots from anthropometry in Europeans, South Asians and African Caribbeans.

ABSTRACT:

Background

South Asians and African Caribbeans experience more cardiometabolic disease than Europeans. Risk factors include visceral (VAT) and subcutaneous abdominal (SAT) adipose tissue, which vary with ethnicity and are difficult to quantify using anthropometry.

Objective

We developed and cross-validated ethnicity and gender-specific equations using anthropometrics to predict VAT and SAT.

Design

669 Europeans, 514 South Asians and 227 African Caribbeans (70 ± 7 years) underwent anthropometric measurement and abdominal CT scanning. South Asian and African Caribbean participants were first-generation migrants living in London. Prediction equations were derived for CT-measured VAT and SAT using stepwise regression, then cross-validated by comparing actual and predicted means.

Results

South Asians had more and African Caribbeans less VAT than Europeans. For basic VAT prediction equations (age and waist circumference), model fit was better in men (R(2) range 0.59-0.71) than women (range 0.35-0.59). Expanded equations (+ weight, height, hip and thigh circumference) improved fit for South Asian and African Caribbean women (R(2) 0.35 to 0.55, and 0.43 to 0.56 respectively). For basic SAT equations, R(2) was 0.69-0.77, and for expanded equations it was 0.72-0.86. Cross-validation showed differences between actual and estimated VAT of <7%, and SAT of <8% in all groups, apart from VAT in South Asian women which disagreed by 16%.

Conclusion

We provide ethnicity- and gender-specific VAT and SAT prediction equations, derived from a large tri-ethnic sample. Model fit was reasonable for SAT and VAT in men, while basic VAT models should be used cautiously in South Asian and African Caribbean women. These equations will aid studies of mechanisms of cardiometabolic disease in later life, where imaging data are not available.

SUBMITTER: Eastwood SV

PROVIDER: S-EPMC3775834 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Estimation of CT-derived abdominal visceral and subcutaneous adipose tissue depots from anthropometry in Europeans, South Asians and African Caribbeans.

Eastwood Sophie V SV Tillin Therese T Wright Andrew A Heasman John J Willis Joseph J Godsland Ian F IF Forouhi Nita N Whincup Peter P Hughes Alun D AD Chaturvedi Nishi N

PloS one 20130917 9

<h4>Background</h4>South Asians and African Caribbeans experience more cardiometabolic disease than Europeans. Risk factors include visceral (VAT) and subcutaneous abdominal (SAT) adipose tissue, which vary with ethnicity and are difficult to quantify using anthropometry.<h4>Objective</h4>We developed and cross-validated ethnicity and gender-specific equations using anthropometrics to predict VAT and SAT.<h4>Design</h4>669 Europeans, 514 South Asians and 227 African Caribbeans (70 ± 7 years) und ...[more]

PMID: 24069381

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Dataset Information

Estimation of CT-derived abdominal visceral and subcutaneous adipose tissue depots from anthropometry in Europeans, South Asians and African Caribbeans.

Background

Objective

Design

Results

Conclusion

Publications

Estimation of CT-derived abdominal visceral and subcutaneous adipose tissue depots from anthropometry in Europeans, South Asians and African Caribbeans.

Similar Datasets

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