Ontology highlight
ABSTRACT:
SUBMITTER: Garton M
PROVIDER: S-EPMC3776228 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Garton Michael M Laughton Charles C
Journal of molecular biology 20130520 16
Eukaryotic chromosomes are capped by telomeres, nucleoprotein complexes that prevent chromosome end-to-end fusions and control cell ageing. Two proteins in this complex, telomere repeat binding factors (TRF1 and TRF2), specifically recognise the double-stranded TTAGGG tandem repeat sequence. TRF1 is a homodimer with roles governing DNA architecture and negatively regulating telomere length. We explore the conformational space of this protein-DNA complex using molecular dynamics and, for the firs ...[more]