The dimeric form of the unphosphorylated response regulator BaeR.
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ABSTRACT:
SUBMITTER: Choudhury HG
PROVIDER: S-EPMC3776340 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
The dimeric form of the unphosphorylated response regulator BaeR.
Choudhury Hassanul G HG Beis Konstantinos K
Protein science : a publication of the Protein Society 20130812 9
Bacterial response regulators (RRs) can regulate the expression of genes that confer antibiotic resistance; they contain a receiver and an effector domain and their ability to bind DNA is based on the dimerization state. This is triggered by phosphorylation of the receiver domain by a kinase. However, even in the absence of phosphorylation RRs can exist in equilibrium between monomers and dimers with phosphorylation shifting the equilibrium toward the dimer form. We have determined the crystal s ...[more]
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