Ontology highlight
ABSTRACT:
SUBMITTER: Miyajima M
PROVIDER: S-EPMC3776841 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Miyajima Masakazu M Nakajima Madoka M Motoi Yumiko Y Moriya Masao M Sugano Hidenori H Ogino Ikuko I Nakamura Eri E Tada Norihiro N Kunichika Miyuki M Arai Hajime H
PloS one 20130918 9
Leucine-rich α2-glycoprotein (LRG) is a protein induced by inflammation. It contains a leucine-rich repeat (LRR) structure and easily binds with other molecules. However, the function of LRG in the brain during aging and neurodegenerative diseases has not been investigated. Here, we measured human LRG (hLRG) concentration in the cerebrospinal fluid (CSF) and observed hLRG expression in post-mortem human cerebral cortex. We then generated transgenic (Tg) mice that over-expressed mouse LRG (mLRG) ...[more]