Ontology highlight
ABSTRACT:
SUBMITTER: Ford CB
PROVIDER: S-EPMC3777616 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Ford Christopher B CB Shah Rupal R RR Maeda Midori Kato MK Gagneux Sebastien S Murray Megan B MB Cohen Ted T Johnston James C JC Gardy Jennifer J Lipsitch Marc M Fortune Sarah M SM
Nature genetics 20130609 7
A key question in tuberculosis control is why some strains of M. tuberculosis are preferentially associated with resistance to multiple drugs. We demonstrate that M. tuberculosis strains from lineage 2 (East Asian lineage and Beijing sublineage) acquire drug resistances in vitro more rapidly than M. tuberculosis strains from lineage 4 (Euro-American lineage) and that this higher rate can be attributed to a higher mutation rate. Moreover, the in vitro mutation rate correlates well with the bacter ...[more]