Ontology highlight
ABSTRACT:
SUBMITTER: Jones JO
PROVIDER: S-EPMC3777980 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130919 9
TOX3 maps to 16q12, a region commonly lost in breast cancers and recently implicated in the risk of developing breast cancer. However, not much is known of the role of TOX3 itself in breast cancer biology. This is the first study to determine the importance of TOX3 mutations in breast cancers. We screened TOX3 for mutations in 133 breast tumours and identified four mutations (three missense, one in-frame deletion of 30 base pairs) in six primary tumours, corresponding to an overall mutation freq ...[more]