Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype.

ABSTRACT: Unraveling the molecular processes that lead from genotype to phenotype is crucial for the understanding and effective treatment of genetic diseases. Knowledge of the causative genetic defect most often does not enable treatment; therefore, causal intermediates between genotype and phenotype constitute valuable candidates for molecular intervention points that can be therapeutically targeted. Mapping genetic determinants of gene expression levels (also known as expression quantitative trait loci or eQTL studies) is frequently used for this purpose, yet distinguishing causation from correlation remains a significant challenge. Here, we address this challenge using extensive, multi-environment gene expression and fitness profiling of hundreds of genetically diverse yeast strains, in order to

SUBMITTER: Gagneur J 

PROVIDER: S-EPMC3778020 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature