Ontology highlight
ABSTRACT:
SUBMITTER: Young BA
PROVIDER: S-EPMC3778061 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Young B A BA Spencer J F JF Ying B B Toth K K Wold W S M WS
Cancer gene therapy 20130809 9
We report that radiation enhances the antitumor efficacy of the oncolytic adenovirus vector VRX-007 in Syrian hamster tumors. We used tumor-specific irradiation of subcutaneous tumors and compared treatment options of radiation alone or combined with VRX-007 and cyclophosphamide (CP). Radiation therapy further augmented the VRX-007-mediated inhibition of tumor growth, in both CP-treated and non-CP-treated hamsters, even though radiation did not lead to increased viral replication in tumors when ...[more]