Ontology highlight
ABSTRACT:
SUBMITTER: Yang MH
PROVIDER: S-EPMC3778089 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Yang Moon Hee MH Laurent Gaelle G Bause Alexandra S AS Spang Robert R German Natalie N Haigis Marcia C MC Haigis Kevin M KM
Molecular cancer research : MCR 20130530 9
<h4>Unlabelled</h4>Activating point mutations in K-RAS are extremely common in cancers of the lung, colon, and pancreas and are highly predictive of poor therapeutic response. One potential strategy for overcoming the deleterious effects of mutant K-RAS is to alter its posttranslational modification. Although therapies targeting farnesylation have been explored, and have ultimately failed, the therapeutic potential of targeting other modifications remains to be seen. Recently, it was shown that ...[more]