Ontology highlight
ABSTRACT:
SUBMITTER: Miletic G
PROVIDER: S-EPMC3778136 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Miletic Gordana G Lippitt Jennifer A JA Sullivan Kristine M KM Miletic Vjekoslav V
Pain 20130615 10
Calcineurin (protein phosphatase 3) regulates synaptic plasticity in the brain. The development of neuropathic pain appears dependent on some of the same mechanisms that underlie brain synaptic plasticity. In this study, we examined whether calcineurin regulates chronic constriction injury (CCI)-elicited plasticity in the spinal dorsal horn. CCI animals exhibited mechanical and thermal hypersensitivity 7 days after ligation of the sciatic nerve. Neither control uninjured nor sham-operated animal ...[more]