Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC3778242 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Wang Jiyong J Tadeo Xavier X Hou Haitong H Tu Patricia G PG Thompson James J Yates John R JR Jia Songtao S
Genes & development 20130901 17
Heterochromatin spreading leads to the silencing of genes within its path, and boundary elements have evolved to constrain such spreading. In fission yeast, heterochromatin at centromeres I and III is flanked by inverted repeats termed IRCs, which are required for proper boundary functions. However, the mechanisms by which IRCs prevent heterochromatin spreading are unknown. Here, we identified Bdf2, which is homologous to the mammalian bromodomain and extraterminal (BET) family double bromodomai ...[more]