Ontology highlight
ABSTRACT:
SUBMITTER: Abdou WM
PROVIDER: S-EPMC3778331 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Abdou Wafaa M WM Ganoub Neven A NA Sabry Eman E
Beilstein journal of organic chemistry 20130822
A high-yielding general synthesis of imidazophosphor ester based tetrazolo[1,5-b]pyridazines is described. A conjugated reaction between 3,6-diazidopyridazine and different types of phosphonyl carbanion reagents followed by intramolecular cyclization afforded the target products, by using sodium ethanolate solution as a reaction medium. Among the products, five compounds, at a dose of 50 mg per kilogram body weight, showed a notable antinociceptive and anti-inflammatory activity without toxic si ...[more]