Ontology highlight
ABSTRACT:
SUBMITTER: Lorrio S
PROVIDER: S-EPMC3778427 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Lorrio Silvia S Romero Alejandro A González-Lafuente Laura L Lajarín-Cuesta Rocío R Martínez-Sanz Francisco J FJ Estrada Martín M Samadi Abdelouahid A Marco-Contelles Jose J Rodríguez-Franco María Isabel MI Villarroya Mercedes M López Manuela G MG de los Ríos Cristóbal C
ACS chemical neuroscience 20130613 9
ITH12246 (ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate) is a 1,8-naphthyridine described to feature an interesting neuroprotective profile in in vitro models of Alzheimer's disease. These effects were proposed to be due in part to a regulatory action on protein phosphatase 2A inhibition, as it prevented binding of its inhibitor okadaic acid. We decided to investigate the pharmacological properties of ITH12246, evaluating its ability to counteract the memory i ...[more]