Ontology highlight
ABSTRACT:
SUBMITTER: Noble R
PROVIDER: S-EPMC3778436 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Noble Robert R Christodoulou Zóe Z Kyes Sue S Pinches Robert R Newbold Chris I CI Recker Mario M
eLife 20130917
Antigenic variation in the human malaria parasite Plasmodium falciparum involves sequential and mutually exclusive expression of members of the var multi-gene family and appears to follow a non-random pattern. In this study, using a detailed in vitro gene transcription analysis of the culture-adapted HB3 strain of P. falciparum, we show that antigenic switching is governed by a global activation hierarchy favouring short and highly diverse genes in central chromosomal location. Longer and more c ...[more]