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The tiger genome and comparative analysis with lion and snow leopard genomes.


ABSTRACT: Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.

SUBMITTER: Cho YS 

PROVIDER: S-EPMC3778509 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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The tiger genome and comparative analysis with lion and snow leopard genomes.

Cho Yun Sung YS   Hu Li L   Hou Haolong H   Lee Hang H   Xu Jiaohui J   Kwon Soowhan S   Oh Sukhun S   Kim Hak-Min HM   Jho Sungwoong S   Kim Sangsoo S   Shin Young-Ah YA   Kim Byung Chul BC   Kim Hyunmin H   Kim Chang-Uk CU   Luo Shu-Jin SJ   Johnson Warren E WE   Koepfli Klaus-Peter KP   Schmidt-Küntzel Anne A   Turner Jason A JA   Marker Laurie L   Harper Cindy C   Miller Susan M SM   Jacobs Wilhelm W   Bertola Laura D LD   Kim Tae Hyung TH   Lee Sunghoon S   Zhou Qian Q   Jung Hyun-Ju HJ   Xu Xiao X   Gadhvi Priyvrat P   Xu Pengwei P   Xiong Yingqi Y   Luo Yadan Y   Pan Shengkai S   Gou Caiyun C   Chu Xiuhui X   Zhang Jilin J   Liu Sanyang S   He Jing J   Chen Ying Y   Yang Linfeng L   Yang Yulan Y   He Jiaju J   Liu Sha S   Wang Junyi J   Kim Chul Hong CH   Kwak Hwanjong H   Kim Jong-Soo JS   Hwang Seungwoo S   Ko Junsu J   Kim Chang-Bae CB   Kim Sangtae S   Bayarlkhagva Damdin D   Paek Woon Kee WK   Kim Seong-Jin SJ   O'Brien Stephen J SJ   Wang Jun J   Bhak Jong J  

Nature communications 20130101


Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-spec  ...[more]

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