Ontology highlight
ABSTRACT:
SUBMITTER: Fletcher MN
PROVIDER: S-EPMC3778544 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
The fibroblast growth factor receptor 2 (FGFR2) locus has been consistently identified as a breast cancer risk locus in independent genome-wide association studies. However, the molecular mechanisms underlying FGFR2-mediated risk are still unknown. Using model systems we show that FGFR2-regulated genes are preferentially linked to breast cancer risk loci in expression quantitative trait loci analysis, supporting the concept that risk genes cluster in pathways. Using a network derived from 2,000 ...[more]