Ontology highlight
ABSTRACT:
SUBMITTER: Kishimoto TK
PROVIDER: S-EPMC3778681 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Kishimoto Takashi Kei TK Viswanathan Karthik K Ganguly Tanmoy T Elankumaran Subbiah S Smith Sean S Pelzer Kevin K Lansing Jonathan C JC Sriranganathan Nammalwar N Zhao Ganlin G Galcheva-Gargova Zoya Z Al-Hakim Ali A Bailey Gregory Scott GS Fraser Blair B Roy Sucharita S Rogers-Cotrone Thomas T Buhse Lucinda L Whary Mark M Fox James J Nasr Moheb M Dal Pan Gerald J GJ Shriver Zachary Z Langer Robert S RS Venkataraman Ganesh G Austen K Frank KF Woodcock Janet J Sasisekharan Ram R
The New England journal of medicine 20080423 23
<h4>Background</h4>There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred after intravenous heparin administration in the United States and Germany.<h4>Methods</h4>Heparin procured from the Food and Drug Administration, consisting of suspect lots of heparin associated with the clinical events as well as control lots of heparin, were screened in ...[more]