Ontology highlight
ABSTRACT:
SUBMITTER: Hawkins ED
PROVIDER: S-EPMC3778729 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Lymphocytes undergo a typical response pattern following stimulation in vivo: they proliferate, differentiate to effector cells, cease dividing and predominantly die, leaving a small proportion of long-lived memory and effector cells. This pattern results from cell-intrinsic processes following activation and the influence of external regulation. Here we apply quantitative methods to study B-cell responses in vitro. Our results reveal that B cells stimulated through two Toll-like receptors (TLRs ...[more]