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Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial.

ABSTRACT: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass.The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal.Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray absorptiometry, and fasting blood was collected for the measurement of plasma zinc at 0, 12, and 18 mo.Thirty-two subjects, 81% of whom were transfusion dependent, completed the study (mean ± SD: 17.1 ± 5.2 y). Plasma zinc was ?70 ?g/dL in 11 subjects at baseline and increased significantly with zinc supplementation (P = 0.014). Use of intention-to-treat analysis and linear models for longitudinal data, adjusted for baseline and pubertal stage, showed that the zinc group had significantly greater increases in whole-body BMC (adjusted mean ± SE: 63 ± 15 g; P = 0.02), and aBMD (0.023 ± 0.006 g/cm(2); P = 0.04) than did the placebo group after 18 mo. Furthermore, adjusted spine and hip aBMD z scores each decreased by 0.3 SDs (both P = 0.04) in the placebo compared with the zinc group over the 18-mo study.In young patients with Thal, zinc supplementation resulted in greater gains in total-body bone mass than did placebo. Zinc was well tolerated and is worthy of investigation in larger trials in Thal patients across a range of ages and disease severity. This trial was registered at clinicaltrials.gov as NCT00459732.

SUBMITTER: Fung EB

PROVIDER: S-EPMC3778866 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial.

Fung Ellen B EB Kwiatkowski Janet L JL Huang James N JN Gildengorin Ginny G King Janet C JC Vichinsky Elliott P EP

The American journal of clinical nutrition 20130814 4

<h4>Background</h4>Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass.<h4>Objective</h4>The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal.<h4>Design</h4>Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy ...[more]

PMID: 23945720

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Dataset Information

Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial.

Publications

Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial.

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