Ontology highlight
ABSTRACT:
SUBMITTER: Molina O
PROVIDER: S-EPMC3778886 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Molina O O Blanco J J Anton E E Vidal F F Volpi E V EV
Genomics 20120828 6
Low-copy repeats (LCRs) constitute 5% of the human genome. LCRs act as substrates for non-allelic homologous recombination (NAHR) leading to genomic structural variation. The aim of this study was to assess the potential of Fiber-FISH for LCRs direct visualization to support investigations of genome architecture within these challenging genomic regions. We describe a set of Fiber-FISH experiments designed for the study of the LCR22-2. This LCR is involved in recurrent reorganizations causing dif ...[more]