Ontology highlight
ABSTRACT:
SUBMITTER: Tang D
PROVIDER: S-EPMC3779133 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Tang Deliang D Kryvenko Oleksandr N ON Mitrache Nicoleta N Do Kieu C KC Jankowski Michelle M Chitale Dhananjay A DA Trudeau Sheri S Rundle Andrew A Belinsky Steven A SA Rybicki Benjamin A BA
The Journal of urology 20130130 1
<h4>Purpose</h4>Gene promoter hypermethylation may be useful as a biomarker for cancer risk in histopathologically benign prostate specimens.<h4>Materials and methods</h4>We performed a nested case-control study of gene promoter methylation status for 5 genes (APC, RARB, CCND2, RASSF1 and MGMT) measured in benign biopsy specimens from 511 prostate cancer case-control pairs. We estimated the overall and race stratified risk of subsequent prostate cancer associated with methylation status.<h4>Resu ...[more]