Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Hernandez I
PROVIDER: S-EPMC3779191 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rodríguez-Hernández Irene I Garcia Juan Luis JL Santos-Briz Angel A Hernández-Laín Aurelio A González-Valero Jose María JM Gómez-Moreta Juan Antonio JA Toldos-González Oscar O Cruz Juan Jesús JJ Martin-Vallejo Javier J González-Sarmiento Rogelio R
PloS one 20130920 9
Malignant astrocytomas are the most aggressive primary brain tumors with a poor prognosis despite optimal treatment. Dysfunction of mismatch repair (MMR) system accelerates the accumulation of mutations throughout the genome causing uncontrolled cell growth. The aim of this study was to characterize the MMR system defects that could be involved in malignant astrocytoma pathogenesis. We analyzed protein expression and promoter methylation of MLH1, MSH2 and MSH6 as well as microsatellite instabili ...[more]