Dataset Information

C-reactive protein levels in African Americans: a diet and lifestyle randomized community trial.

ABSTRACT:

Background

Chronic inflammation is linked to poor lifestyle behaviors and a variety of chronic diseases that are prevalent among African Americans, especially in the southeastern U.S.

Purpose

The goal of the study was to test the effect of a community-based diet, physical activity, and stress reduction intervention conducted in 2009-2012 on reducing serum C-reactive protein (CRP) in overweight and obese African-American adults.

Methods

An RCT intervention was designed jointly by members of African-American churches and academic researchers. In late 2012, regression (i.e., mixed) models were fit that included both intention-to-treat and post hoc analyses conducted to identify important predictors of intervention success. Outcomes were assessed at 3 months and 1 year.

Results

At baseline, the 159 individuals who were recruited in 13 churches and had evaluable outcome data were, on average, obese (BMI=33.1 [±7.1]) and had a mean CRP level of 3.7 (±3.9) mg/L. Reductions were observed in waist-to-hip ratio at 3 months (2%, p=0.03) and 1 year (5%, p<0.01). In female participants attending ?60% of intervention classes, there was a significant decrease in CRP at 3 months of 0.8 mg/L (p=0.05), but no change after 1 year. No differences were noted in BMI or interleukin-6.

Conclusions

In overweight/obese, but otherwise "healthy," African-American church members with very high baseline CRP levels, this intervention produced significant reductions in CRP at 3 and 12 months, and in waist-to-hip ratio, which is an important anthropometric predictor of overall risk of inflammation and downstream health effects.

Trial registration

This study is registered at www.clinicaltrials.gov NCT01760902.

SUBMITTER: Hebert JR

PROVIDER: S-EPMC3779347 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Publications

C-reactive protein levels in African Americans: a diet and lifestyle randomized community trial.

Hébert James R JR Wirth Michael M Davis Lisa L Davis Briana B Harmon Brook E BE Hurley Thomas G TG Drayton Ruby R Angela Murphy E E Shivappa Nitin N Wilcox Sara S Adams Swann A SA Brandt Heather M HM Blake Christine E CE Armstead Cheryl A CA Steck Susan E SE Blair Steven N SN

American journal of preventive medicine 20131001 4

<h4>Background</h4>Chronic inflammation is linked to poor lifestyle behaviors and a variety of chronic diseases that are prevalent among African Americans, especially in the southeastern U.S.<h4>Purpose</h4>The goal of the study was to test the effect of a community-based diet, physical activity, and stress reduction intervention conducted in 2009-2012 on reducing serum C-reactive protein (CRP) in overweight and obese African-American adults.<h4>Methods</h4>An RCT intervention was designed joint ...[more]

PMID: 24050419

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Dataset Information

C-reactive protein levels in African Americans: a diet and lifestyle randomized community trial.

Background

Purpose

Methods

Results

Conclusions

Trial registration

Publications

C-reactive protein levels in African Americans: a diet and lifestyle randomized community trial.

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