Ontology highlight
ABSTRACT:
SUBMITTER: Patel AS
PROVIDER: S-EPMC3779448 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Patel Ashish S AS Smith Alberto A Nucera Silvia S Biziato Daniela D Saha Prakash P Attia Rizwan Q RQ Humphries Julia J Mattock Katherine K Grover Steven P SP Lyons Oliver T OT Guidotti Luca G LG Siow Richard R Ivetic Aleksandar A Egginton Stuart S Waltham Matthew M Naldini Luigi L De Palma Michele M Modarai Bijan B
EMBO molecular medicine 20130507 6
A third of patients with critical limb ischemia (CLI) will eventually require limb amputation. Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic limbs has produced modest results. The TIE2-expressing monocytes/macrophages (TEMs) are a myeloid cell subset known to be highly angiogenic in tumours. This study aimed to examine the kinetics of TEMs in patients with CLI and whether these cells promote neovascularization of the ischemic limb. Here we show that there ...[more]