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The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis.


ABSTRACT: Type I IFNs (IFN-? and IFN-?) and type II IFN (IFN-?) mediate both regulation and inflammation in multiple sclerosis, neuromyelitis optica, and in experimental autoimmune encephalomyelitis (EAE). However, the underlying mechanism for these Janus-like activities of type I and II IFNs in neuroinflammation remains unclear. Although endogenous type I IFN signaling provides a protective response in neuroinflammation, we find that when IFN-? signaling is ablated, type I IFNs drive inflammation, resulting in exacerbated EAE. IFN-? has a disease stage-specific opposing function in EAE. Treatment of mice with IFN-? during the initiation phase of EAE leads to enhanced severity of disease. In contrast, IFN-? treatment during the effector phase attenuated disease. This immunosuppressive activity of IFN-? required functional type I IFN signaling. In IFN-?/? receptor-deficient mice, IFN-? treatment during effector phase of EAE exacerbated disease. Using an adoptive transfer EAE model, we found that T cell-intrinsic type I and II IFN signals are simultaneously required to establish chronic EAE by encephalitogenic Th1 cells. However, in Th17 cells loss of either IFN signals leads to the development of a severe chronic disease. The data imply that type I and II IFN signals have independent but nonredundant roles in restraining encephalitogenic Th17 cells in vivo. Collectively, our data show that type I and II IFNs function in an integrated manner to regulate pathogenesis in EAE.

SUBMITTER: Naves R 

PROVIDER: S-EPMC3779698 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis.

Naves Rodrigo R   Singh Simer P SP   Cashman Kevin S KS   Rowse Amber L AL   Axtell Robert C RC   Steinman Lawrence L   Mountz John D JD   Steele Chad C   De Sarno Patrizia P   Raman Chander C  

Journal of immunology (Baltimore, Md. : 1950) 20130819 6


Type I IFNs (IFN-α and IFN-β) and type II IFN (IFN-γ) mediate both regulation and inflammation in multiple sclerosis, neuromyelitis optica, and in experimental autoimmune encephalomyelitis (EAE). However, the underlying mechanism for these Janus-like activities of type I and II IFNs in neuroinflammation remains unclear. Although endogenous type I IFN signaling provides a protective response in neuroinflammation, we find that when IFN-γ signaling is ablated, type I IFNs drive inflammation, result  ...[more]

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