Ontology highlight
ABSTRACT:
SUBMITTER: Hu S
PROVIDER: S-EPMC3779706 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Hu Shi S Liang Shuaiyi S Guo Huaizu H Zhang Dapeng D Li Hui H Wang Xiaoze X Yang Weili W Qian Weizhu W Hou Sheng S Wang Hao H Guo Yajun Y Lou Zhiyong Z
The Journal of biological chemistry 20130813 38
TNFα-targeting therapy with the use of the drugs Etanercept, Infliximab, and Adalimumab is used in the clinical treatment of various inflammatory and immune diseases. Although all of these reagents function to disrupt the interaction between TNFα and its receptors, clinical investigations showed the advantages of Adalimumab treatment compared with Etanercept and Infliximab. However, the underlying molecular mechanism of action of Adalimumab remains unclear. In our previous work, we presented str ...[more]