Ontology highlight
ABSTRACT:
SUBMITTER: Croft W
PROVIDER: S-EPMC3779728 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Croft Wayne W Hill Claire C McCann Eilish E Bond Michael M Esparza-Franco Manuel M Bennett Jeannette J Rand David D Davey John J Ladds Graham G
The Journal of biological chemistry 20130730 38
G protein-coupled receptors (GPCRs) can interact with regulator of G protein signaling (RGS) proteins. However, the effects of such interactions on signal transduction and their physiological relevance have been largely undetermined. Ligand-bound GPCRs initiate by promoting exchange of GDP for GTP on the Gα subunit of heterotrimeric G proteins. Signaling is terminated by hydrolysis of GTP to GDP through intrinsic GTPase activity of the Gα subunit, a reaction catalyzed by RGS proteins. Using yeas ...[more]