Ontology highlight
ABSTRACT:
SUBMITTER: Le Nours J
PROVIDER: S-EPMC3779744 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Le Nours Jérôme J Paton Adrienne W AW Byres Emma E Troy Sally S Herdman Brock P BP Johnson Matthew D MD Paton James C JC Rossjohn Jamie J Beddoe Travis T
The Journal of biological chemistry 20130806 38
Pathogenic strains of Escherichia coli produce a number of toxins that belong to the AB5 toxin family, which comprise a catalytic A-subunit that induces cellular dysfunction and a B-pentamer that recognizes host glycans. Although the molecular actions of many of the individual subunits of AB5 toxins are well understood, how they self-associate and the effect of this association on cytotoxicity are poorly understood. Here we have solved the structure of the holo-SubAB toxin that, in contrast to o ...[more]