A human gut microbial gene catalogue established by metagenomic sequencing.
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ABSTRACT:
SUBMITTER: Qin J
PROVIDER: S-EPMC3779803 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
A human gut microbial gene catalogue established by metagenomic sequencing.
Qin Junjie J Li Ruiqiang R Raes Jeroen J Arumugam Manimozhiyan M Burgdorf Kristoffer Solvsten KS Manichanh Chaysavanh C Nielsen Trine T Pons Nicolas N Levenez Florence F Yamada Takuji T Mende Daniel R DR Li Junhua J Xu Junming J Li Shaochuan S Li Dongfang D Cao Jianjun J Wang Bo B Liang Huiqing H Zheng Huisong H Xie Yinlong Y Tap Julien J Lepage Patricia P Bertalan Marcelo M Batto Jean-Michel JM Hansen Torben T Le Paslier Denis D Linneberg Allan A Nielsen H Bjørn HB Pelletier Eric E Renault Pierre P Sicheritz-Ponten Thomas T Turner Keith K Zhu Hongmei H Yu Chang C Li Shengting S Jian Min M Zhou Yan Y Li Yingrui Y Zhang Xiuqing X Li Songgang S Qin Nan N Yang Huanming H Wang Jian J Brunak Søren S Doré Joel J Guarner Francisco F Kristiansen Karsten K Pedersen Oluf O Parkhill Julian J Weissenbach Jean J Bork Peer P Ehrlich S Dusko SD Wang Jun J
Nature 20100301 7285
To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, approximately 150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbia ...[more]
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