Dataset Information

Asthma related to cleaning agents: a clinical insight.

ABSTRACT:

Objective

To determine the agents causing asthmatic reactions during specific inhalation challenges (SICs) in workers with cleaning-related asthma symptoms and to assess the pattern of bronchial responses in order to identify the mechanisms involved in cleaning-related asthma.

Design

A retrospective case series analysis.

Setting

The study included all participants who completed an SIC procedure with the cleaning/disinfection products suspected of causing work-related asthma over the period 1992-2011 in a tertiary centre, which is the single specialised centre of the French-speaking part of Belgium where all participants with work-related asthma are referred to for SIC.

Results

The review identified 44 participants who completed an SIC with cleaning/disinfection agents. Challenge exposure to the suspected cleaning agents elicited a ?20% fall in forced expiratory volume in 1 s (FEV1) in 17 (39%) participants. The cleaning products that induced a positive SIC contained quaternary ammonium compounds (n=10), glutaraldehyde (n=3), both of these agents (n=1) and ethanolamines (n=2). Positive SICs were associated with a significant decrease in the median (IQR) value of the provocative concentration of histamine causing a 20% fall in FEV1 (PC20) from 1.4 (0.2-4.2) mg/mL at baseline to 0.5 (0.4-3.0) mg/mL after the challenge and a significant increase in sputum eosinophils from 1.8 (0.8-7.2)% at baseline to 10.0 (4.1-15.9)% 7 h after the challenge exposure while these parameters did not significantly change in participants with a negative SIC. Overall, 11 of 17 participants with positive SICs showed greater than threefold decrease in postchallenge histamine PC20 value, a >2% increase in sputum eosinophils, or both of these outcomes.

Conclusions

These data indicate that a substantial proportion of workers who experience asthma symptoms related to cleaning materials show a pattern of bronchial reaction consistent with sensitiser-induced occupational asthma. The results also suggest that quaternary ammonium compounds are the principal cause of sensitiser-induced occupational asthma among cleaners.

SUBMITTER: Vandenplas O

PROVIDER: S-EPMC3780339 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Asthma related to cleaning agents: a clinical insight.

Vandenplas Olivier O D'Alpaos Vinciane V Evrard Geneviève G Jamart Jacques J Thimpont Joel J Huaux François F Renauld Jean-Christophe JC

BMJ open 20130919 9

<h4>Objective</h4>To determine the agents causing asthmatic reactions during specific inhalation challenges (SICs) in workers with cleaning-related asthma symptoms and to assess the pattern of bronchial responses in order to identify the mechanisms involved in cleaning-related asthma.<h4>Design</h4>A retrospective case series analysis.<h4>Setting</h4>The study included all participants who completed an SIC procedure with the cleaning/disinfection products suspected of causing work-related asthma ...[more]

PMID: 24056489

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Dataset Information

Asthma related to cleaning agents: a clinical insight.

Objective

Design

Setting

Results

Conclusions

Publications

Asthma related to cleaning agents: a clinical insight.

Similar Datasets

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