Ontology highlight
ABSTRACT:
SUBMITTER: Han G
PROVIDER: S-EPMC3780964 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Han Gangwen G Bian Li L Li Fulun F Cotrim Ana A Wang Donna D Lu Jianbo J Deng Yu Y Bird Gregory G Sowers Anastasia A Mitchell James B JB Gutkind J Silvio JS Zhao Rui R Raben David D ten Dijke Peter P Refaeli Yosef Y Zhang Qinghong Q Wang Xiao-Jing XJ
Nature medicine 20130310 4
We report that K5.Smad7 mice, which express a Smad7 transgene under the control of a keratin 5 promoter, were resistant to radiation-induced oral mucositis, a painful oral ulceration. In addition to nuclear factor κB (NF-κB) activation, which is known to contribute to oral mucositis, we found activated transforming growth factor β (TGF-β) signaling in cells from this condition. Smad7 dampened both pathways to attenuate inflammation, growth inhibition and apoptosis. Additionally, Smad7 promoted o ...[more]