Ontology highlight
ABSTRACT:
SUBMITTER: Avdoshina V
PROVIDER: S-EPMC3780967 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Avdoshina Valeriya V Mocchetti Italo I Liu Chenglong C Young Mary A MA Anastos Kathryn K Cohen Mardge M Crystal Howard H Pearce Celeste L CL Golub Elizabeth T ET Tractenberg Rochelle E RE
Journal of acquired immune deficiency syndromes (1999) 20131001 2
Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and ...[more]