Ontology highlight
ABSTRACT:
SUBMITTER: Edwards AL
PROVIDER: S-EPMC3781208 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Chemistry & biology 20130701 7
PUMA is a proapoptotic BCL-2 family member that drives the apoptotic response to a diversity of cellular insults. Deciphering the spectrum of PUMA interactions that confer its context-dependent proapoptotic properties remains a high priority goal. Here, we report the synthesis of PUMA SAHBs, structurally stabilized PUMA BH3 helices that, in addition to broadly targeting antiapoptotic proteins, directly bind to proapoptotic BAX. NMR, photocrosslinking, and biochemical analyses revealed that PUMA ...[more]