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Patterns of ?-cell autoantibody appearance and genetic associations during the first years of life.

ABSTRACT: We analyzed demographic and genetic differences between children with various diabetes-associated autoantibodies reflecting the autoimmune process. In a prospective birth cohort comprising children with HLA-conferred susceptibility to type 1 diabetes (T1D), the pattern of autoantibody appearance was analyzed in 520 children with advanced ?-cell autoimmunity associated with high risk for disease. In 315 cases, a single biochemical autoantibody could be identified in the first positive sample as insulin (insulin autoantibody [IAA]) in 180, as GAD (GAD antibody [GADA]) in 107, and as IA-2 antigen (IA-2 antibody [IA-2A]) in 28. The age at seroconversion differed significantly between the three groups (P = 0.003). IAA as the first autoantibody showed a peak time of appearance during the second year of life, whereas GADA as the first autoantibody peaked later, between 3 and 5 years of age. The risk-associated insulin gene rs689 A/A genotypes were more frequent in children with IAA as the first autoantibody compared with the other children (P = 0.002). The primary autoantigen in the development of ?-cell autoimmunity and T1D seems to strongly correlate with age and genetic factors, indicating heterogeneity in the initiation of the disease process.

SUBMITTER: Ilonen J

PROVIDER: S-EPMC3781470 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Patterns of β-cell autoantibody appearance and genetic associations during the first years of life.

Ilonen Jorma J Hammais Anna A Laine Antti-Pekka AP Lempainen Johanna J Vaarala Outi O Veijola Riitta R Simell Olli O Knip Mikael M

Diabetes 20130708 10

We analyzed demographic and genetic differences between children with various diabetes-associated autoantibodies reflecting the autoimmune process. In a prospective birth cohort comprising children with HLA-conferred susceptibility to type 1 diabetes (T1D), the pattern of autoantibody appearance was analyzed in 520 children with advanced β-cell autoimmunity associated with high risk for disease. In 315 cases, a single biochemical autoantibody could be identified in the first positive sample as i ...[more]

PMID: 23835325

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Patterns of ?-cell autoantibody appearance and genetic associations during the first years of life.

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Patterns of β-cell autoantibody appearance and genetic associations during the first years of life.

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