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Structural basis of signal transduction in the TNF receptor superfamily.

ABSTRACT: Members of the tumor necrosis factor receptor superfamily play key roles in innate and adaptive immunity. Here, we review recent structural studies in the intracellular signal transduction of these receptors. A central theme revealed from these structural studies is that upon ligand binding, multiple intracellular proteins form higher-order signaling machines to transduce and amplify receptor activation information to different cellular fates, including NF-?B activation, apoptosis, and programmed necrosis. These studies open a new vista for understanding the biophysical principles in these signaling cascades.

SUBMITTER: Li J

PROVIDER: S-EPMC3781945 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Structural basis of signal transduction in the TNF receptor superfamily.

Li Jixi J Yin Qian Q Wu Hao H

Advances in immunology 20130101

Members of the tumor necrosis factor receptor superfamily play key roles in innate and adaptive immunity. Here, we review recent structural studies in the intracellular signal transduction of these receptors. A central theme revealed from these structural studies is that upon ligand binding, multiple intracellular proteins form higher-order signaling machines to transduce and amplify receptor activation information to different cellular fates, including NF-κB activation, apoptosis, and programme ...[more]

PMID: 23886067

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