Identification of TET1 Partners That Control Its DNA-Demethylating Function.
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ABSTRACT:
SUBMITTER: Cartron PF
PROVIDER: S-EPMC3782005 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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Identification of TET1 Partners That Control Its DNA-Demethylating Function.
Cartron Pierre-François PF Nadaradjane Arulraj A Lepape Fiona F Lalier Lisenn L Gardie Betty B Vallette François M FM
Genes & cancer 20130501 5-6
Several recent reports have identified TET1 as the main enzyme modulating DNA methylation and gene transcription via hydroxylation of 5-methylcytosine. However, little is known about the protein network that controls TET1 activity. By using a new proximity ligation in situ assay, we identified MeCP2, HDAC1/6/7, EZH2, mSin3A, PCNA, and LSD1 as TET1-interacting proteins. We also discerned that TET1/PCNA acts as a demethylator of the cyclical methylation/demethylation process, the perturbation of w ...[more]
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