Ontology highlight
ABSTRACT:
SUBMITTER: Kalhor R
PROVIDER: S-EPMC3782096 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Kalhor Reza R Tjong Harianto H Jayathilaka Nimanthi N Alber Frank F Chen Lin L
Nature biotechnology 20111225 1
We describe tethered conformation capture (TCC), a method for genome-wide mapping of chromatin interactions. By performing ligations on solid substrates rather than in solution, TCC substantially enhances the signal-to-noise ratio, thereby facilitating a detailed analysis of interactions within and between chromosomes. We identified a group of regions in each chromosome in human cells that account for the majority of interchromosomal interactions. These regions are marked by high transcriptional ...[more]