High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
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ABSTRACT:
SUBMITTER: Lugade AA
PROVIDER: S-EPMC3782165 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
Lugade Amit A AA Kalathil Suresh S Miller Austin A Iyer Renuka R Thanavala Yasmin Y
Oncoimmunology 20130430 7
The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell function in HCC. ...[more]
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